L.A. Chargers at Cleveland 1:00 PM ET
The Cleveland Browns won one game during a two-season span, and it came against the then-San Diego Chargers on Christmas Eve 2016. Fast forward to 2018 and the Browns are looking to record their third victory in six games when they host the now-Los Angeles Chargers on Sunday.
Buffalo at Houston 1:00 PM ET
The Houston Texans have found themselves in close games in each of their first five contests, and they’ve won the last two in overtime. They’ll try to make it three victories in a row when they host the Buffalo Bills on Sunday.
Pittsburgh at Cincinnati 1:00 PM ET
The Cincinnati Bengals are off to a hot start and sit in first place in the AFC North, but they are not taking that position for granted. The Bengals will try to make a statement and push aside one of their biggest rivals when they host the Pittsburgh Steelers on Sunday.
Tampa Bay at Atlanta 1:00 PM ET
Jameis Winston will return to his starting role when the Tampa Bay Buccaneers visit the Atlanta Falcons for an NFC South showdown on Sunday. The Falcons have won three straight against their division rivals and need to make it four in a row to have any chance of salvaging their season.
Chicago at Miami 1:00 PM ET
The Chicago Bears find themselves atop the NFC North on the strength of their first three-game winning streak in five years, this after mustering a total of 14 victories to finish in the division's basement in each of the last three seasons. Fresh off a bye, the Bears look to dominate their second straight Sunshine State foe on Sunday when they visit the Miami Dolphins at Hard Rock Stadium.
Carolina at Washington 1:00 PM ET
The Carolina Panthers will try to continue more than a decade of domination over the Washington Redskins when they visit the nation’s capital for a showdown on Sunday. The Panthers have won five straight meetings dating to 2006, including a 26-15 victory at Washington in the most recent clash in 2016.
Seattle at Oakland 1:00 PM ET
The Oakland Raiders make their second visit to Wembley Stadium in London on Sunday and hope for a better result when they take the field as the home team against an old rival in the Seattle Seahawks. Oakland, which is off to a disappointing start in coach Jon Gruden's return to the sideline, dropped a 38-14 decision to Miami at Wembley in 2014.
Arizona at Minnesota 1:00 PM ET
The Minnesota Vikings made a statement by avenging their NFC Championship Game loss last week and are bidding for their first winning streak of the season on Sunday when they host the Arizona Cardinals. The Vikings, however, would be wise not to overlook the Cardinals after being upended earlier this season by Buffalo, which also entered that contest as a double-digit underdog.
Indianapolis at N.Y. Jets 1:00 PM ET
Rookie quarterback Sam Darnold is a member of the New York Jets thanks to a trade that allowed the franchise to move up three slots in this year's draft. The team that made that trade with the Jets -- the Indianapolis Colts -- will get their first look at Darnold on Sunday at MetLife Stadium as his Jets bid for back-to-back home wins.
L.A. Rams at Denver 4:05 PM ET
The Los Angeles Rams look to maintain their unbeaten record when they visit the Denver Broncos on Sunday. Los Angeles has been soaring behind a unit that leads the NFL in total offense (468.4 yards per game) and ranks third in scoring (34.6 points) as it faces a Denver squad that has lost three straight games.
Jacksonville at Dallas 4:25 PM ET
The Jacksonville Jaguars came up well short in a battle for AFC supremacy last weekend, getting wiped out by the high-powered and undefeated Kansas City Chiefs. Jacksonville will look to shake off the lopsided defeat when it plays its second inter-conference game of the season with a visit to the struggling Dallas Cowboys on Sunday afternoon.
Baltimore at Tennessee 4:25 PM ET
The Tennessee Titans are used to playing close games but wouldn't mind running it up a bit on the scoreboard. The Titans will try to reach 30 points for the first time this season and earn a key AFC win when they host the Baltimore Ravens on Sunday.
Kansas City at New England 8:20 PM ET
Five Super Bowl championships and three NFL Most Valuable Player awards has Tom Brady in the conversation of greatest quarterback of all time, but he may be taking a back seat in his upcoming matchup. Patrick Mahomes is off to a sizzling start to the season and will look to keep the Kansas City Chiefs perfect when they visit the Patriots on Sunday night.